Ultra-Fast Solution Switching System — LSS-3000
The Burleigh Piezoelectric Ultra-fast Solution Switching Systems can change the chemical environment of a whole cell or excised patch with submillisecond time resolution. These systems are complete, practical and easy-to-implement approaches for rapidly moving a theta tube and its exiting solution stream. Now you can uncover the actual kinetics of ion channels, reconstruct the naturally occurring conditions at the synapse of a neuron and eliminate the problem of desensitization resulting from longer time exposures to a drug in pharmacological studies.
One-way solution switching in less than 100 µs
Two-way solution pulses in less than 1 ms
Smooth stable and accurate linear motion using solid-state PZT actuators integrated
with monolithic flexure stages
Simple electronic integration with Axon PClamp or other patch-clamp hardware
and software
Universal-angle theta-tube mounting system
Complete microscope mounting solutions
Up to 300 µm PZT travel for easy alignment
Integrated manual stages and adjustments for easy coarse alignment
Up to 20 times faster than stepper motor systems
Overcomes problems of desensitization with slower systems
LSS-3000 Series Ultra-fast Solution Switching System
This consists of components with the following modules:
LSS-3100 System
PZS-100HS MicroStage (105µm travel)
PZ-150M Amplifier/Driver
LS-10 Mounting System for MicroStage & Pipette
CP-300 Manual Stage Assembly & PZ-22 cable
Components
PZS-100HS & PS-200 Microstages
These are PZT actuated flexure stages that generate straight vibration-free
motion in a small robust package. The micropipette is mounted on the top surface
which moves by amplified PZT motion relative to the fixed bottom of the stage.
This design is compact and rugged with low pitch and yaw errors. The minimum
time to move the full range of motion is less than 1 millisecond.
LS-10 Mounting System and CP-300 Manual Stage Assembly
These combine to provide a very stable, yet flexible universal mounting system
for integration with virtually any microscope.
All PZS Series MicroStages can be mounted onto the LS-10 mounting system
Accommodates pipettes and theta tubing up to 3 mm diameter
The LS-10 can be used separately with other manual stages that can hold its 0.75-inch rod
The CP-300 provides six degrees of freedom. The X,Y and Z axes have manual adjusters with 25 mm travel and 10 µm resolution.
The CP-300 can be mounted onto all Burleigh PCS-500 Series Microscope Mounts
The PZ-150M Amplifier/Driver
This is an analog high-voltage power supply with sufficient power and frequency
response to drive the PZS MicroStages at maximum speed. The power supply accepts
0 to ± 10 V input. The actual output voltage is shown on a digital front-panel
display. The PZ-150M does not have the programmable intelligence of the PZ-100.
Thus, the step size, ramp shape and speed are set by the input drive signal.
Gain and DC offset are adjusted by front-panel knobs.
PCS-500 Series Microscope Mounts
A number of optional microscope mounts are available to mount these systems onto a variety of commercial microscopes.